Variable number of TMC1-dependent mechanotransducer channels underlie tonotopic conductance gradients in the cochlea
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چکیده
منابع مشابه
Tonotopic Variation in the Conductance of the Hair Cell Mechanotransducer Channel
Hair cells in the vertebrate cochlea are arranged tonotopically with their characteristic frequency (CF), the sound frequency to which they are most sensitive, changing systematically with position. Single mechanotransducer channels of hair cells were characterized at different locations in the turtle cochlea. In 2.8 mM external Ca2+, the channel's chord conductance was 118 pS (range 80-163 pS)...
متن کاملSubunit determination of the conductance of hair-cell mechanotransducer channels.
Cochlear hair cells convert sound stimuli into electrical signals by gating of mechanically sensitive ion channels in their stereociliary (hair) bundle. The molecular identity of this ion channel is still unclear, but its properties are modulated by accessory proteins. Two such proteins are transmembrane channel-like protein isoform 1 (TMC1) and tetraspan membrane protein of hair cell stereocil...
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The mammalian cochlea is exquisitely designed to decompose complex sounds into their component frequencies, accounting in part for the superb auditory discrimination displayed by many species. To perform this task, numerous mechanical and electrical specializations are graded along the length of the cochlea that create a tonotopic map in which sounds of different frequencies produce maximal res...
متن کاملDevelopmental changes in the cochlear hair cell mechanotransducer channel and their regulation by transmembrane channel–like proteins
Vibration of the stereociliary bundles activates calcium-permeable mechanotransducer (MT) channels to initiate sound detection in cochlear hair cells. Different regions of the cochlea respond preferentially to different acoustic frequencies, with variation in the unitary conductance of the MT channels contributing to this tonotopic organization. Although the molecular identity of the MT channel...
متن کاملConductance and block of hair-cell mechanotransducer channels in transmembrane channel–like protein mutants
Transmembrane channel-like (TMC) proteins TMC1 and TMC2 are crucial to the function of the mechanotransducer (MT) channel of inner ear hair cells, but their precise function has been controversial. To provide more insight, we characterized single MT channels in cochlear hair cells from wild-type mice and mice with mutations in Tmc1, Tmc2, or both. Channels were recorded in whole-cell mode after...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2018
ISSN: 2041-1723
DOI: 10.1038/s41467-018-04589-8